Morphological Correlate to a Cholinergic Sympathetic Function
نویسندگان
چکیده
منابع مشابه
Sympathetic postganglionic cholinergic fibres.
When the postganglionic fibres to the nictitating membrane are stimulated in a cat treated with reserpine, the membrane contracts. The contraction is increased after the injection of eserine and is abolished with atropine. Thus the fibres stimulated appear to be cholinergic. When the splenic nerve is stimulated in a cat treated with reserpine there is similar evidence of the presence of choline...
متن کاملMorphological and Biochemical Studies on the Development of Cholinergic Properties in Cultured Sympathetic Neurons
Superior cervical ganglion (SCG) neurons taken from perinatal rats and dissociated in culture develop cholinergic properties . This report examines this "plasticity" of neurotransmitter function with regard to its dependence on the stage of neuronal development. Explants of SCG from rats ranging in age from 2 d to adult were cultured, and the number of neurons surviving after 6 wk in culture wa...
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A clonal rat sympathetic nerve cell line, PC12, binds iodinated cY-bungarotoxin. The binding is saturable and is inhibited by a variety of cholinergic agonists and antagonists. The pseudo-first order rate constant for binding is 2.1 x lo” Mm1 s-l at 22”. In contrast to the cu-bungarotoxin binding reaction found with muscle, the binding to PC12 is reversible with a first order rate constant of 4...
متن کاملalpha-Bungarotoxin binding and cholinergic receptor function on a rat sympathetic nerve line.
A clonal rat sympathetic nerve cell line, PC12, binds iodinated alpha-bungarotoxin. The binding is saturable and is inhibited by a variety of cholinergic agonists and antagonists. The pseudo-first order rate constant for binding is 2.1 x 10(5) M-1 S-1 at 22 degrees. In contrast to the alpha-bungarotoxin binding reaction found with muscle, the binding to PC12 is reversible with a first order rat...
متن کاملMorphological and biochemical studies on the development of cholinergic properties in cultured sympathetic neurons. II. Dependence on postnatal age
Superior cervical ganglion (SCG) neurons taken from perinatal rats and dissociated in culture develop cholinergic properties. This report examines this "plasticity" of neurotransmitter function with regard to its dependence on the stage of neuronal development. Explants of SCG from rats ranging in age from 2 d to adult were cultured, and the number of neurons surviving after 6 wk in culture was...
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ژورنال
عنوان ژورنال: Nature
سال: 1962
ISSN: 0028-0836,1476-4687
DOI: 10.1038/194298a0